Download Advances in Cancer Research, Vol. 3 by Jeese P. Greenstein, Alexander Haddow (Eds.) PDF

By Jeese P. Greenstein, Alexander Haddow (Eds.)

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560°C. Surface Temperature 900°C. 900°C. 700°C. 800°C. + + + + 28 RICHARD DOLL Closely similar temperatures in burning cigarettes have been recorded by Wynder, Graham, and Croninger (1953) and by Hamer (1954), and a similar temperature for combustion in pipes was recorded by Cooper et al. (1932). If Lindsey’s observations on the presence of benzpyrene in the smoke from tobacco burnt in pipes are confirmed, it would seem likely that polycyclic compounds can be formed a t lower temperatures than have, hitherto, been thought to be necessary.

It is, however, of interest to make the comparisons, provided that the deficiencies of the data are recognized. Statistics for 8 countries have been collected by Nielsen and Clemmesen (1955), and these have largely been drawn on, in the preparation of Figs. 6 and 7. I n Fig. 6, the male death rate from lung cancer in 11 countries in 1950 (or in the nearest year for which the information is available) has been plotted against the annual consumption of all tobacco products per head of the population 20 years earlier; in Fig.

The data on the significance of inhaling are also conflicting, and it is uncertain whether the difference between the effects of smoking tobacco in the form of cigarettes and in a pipe can be attributed to differences in the extent to which the smoke is usually inhaled or whether it is necessary to postulate some other mechanism. These fields of uncertainty are, however, small in relation to the extent of established knowledge and do not justify throwing doubt on the main conclusion. 2. Industrial Hazards When Smith (1953) presented his report to the Louvain symposium, five industrial processes (the mining of certain radioactive ores, the refining of nickel, and the manufacture of asbestos, chromates, and coal gas) had been recognized as involving a special risk of lung cancer; and there was fairly strong evidence to suggest that exposure t o heavy concentrations of arsenic in the air-of up to 1000 pg.

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