By Felix R. Althaus, Hanna E. Kleczkowska (auth.), Rafael Alvarez-Gonzalez (eds.)
This unique factor of Molecular and mobile Biochemistry includes twenty-two chosen learn papers and studies from a complete of 1 hundred and ten shows given on the twelfth foreign Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to melanoma, held in Cancun, Mexico, may possibly 10-14, 1997. The Symposium used to be hosted through the Sociedad Mexicana de Bioquimica and used to be subsidized by way of the collage of North Texas well-being technological know-how middle, fortress worthy, TX, united states.
This quantity presents a cutting-edge resource of data for easy scientists and clinicians who're drawn to the molecular, biochemical, and mobile elements of protein-(ADP-ribose) move reactions in human overall healthiness and disease.
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Additional resources for ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer
Carcinogenesis 7: 1267-1271, 1986 Bhattacharyya N, Bhattacharjee SB: The eirect of nicotinamide onNmethyl-N' -nitro-N-nitrosoguanidine induced killing and mutation. Chem Bioi Interact 60: 287-295, 1986 Nunbhakdi V, Jacobson EL: Effects of a poly(ADP-ribose) polymerase inhibitor on mutation frequencies in dividing and quiescent C3H10TI12 cells. Mutat Res 180: 249-256,1987 Ghosh R, Bhattacharjee SB: Influence of benzamide on killing and mutation of density-inhibited V79 cells by MNNG. Mutat Res 225: 137-141,1989 Magnusson J, Ramel C: Inhibitor of poly(ADP-ribose)transferase potentiates the recombinogenic but not the mutagenic action of alkylating agents in somatic cells in vivo in Drosophila melanogaster.
Mol Cell Biochem 138: 33-37, 1994 7. Mendoza-Alvarez H, Alvarez-Gonzalez R: Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular. J BioI Chern 268: 22575-22580, 1993 8. Lautier D, Lagueux J, Thibodeau J, Menard L, Poirier GG: Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 122: 171-193,1993 9. Berger NA, Berger SJ: Metabolic consequences of DNA damage: The role of poly (ADP-ribose) polymerase as mediator of the suicide response.
Most Table 2. Clostridal toxins that modify and inactivate Rho GTPases. Exoenzymeltoxin Enzymatic activity/substrate Target protein Clostridium botulinum exoenzyme C3 Clostridium limosum transferase Clostridium difficile toxin A Clostridium difficile toxin B Clostridium sordellii hemorrhagic toxin Clostridium sordellii lethal toxin Clostridium novyi a-toxin ADP-ribosylation NAD ADP-ribosylation NAD UDP-glucosylation UDP-Glc UDP-glucosylation UDP-Glc UDP-glucosylation UDP-Glc UDP-glucosylation UDP-Glc UDP-glucosaminylation UDP-GIcNAc RhoA-C RhoA-C All Rho, Rae, & Cdc42 All Rho , Rae, & Cdc42 All Rho, Rae , & Cdc42 Rae , Cdc42, Ras, Rap, & Ral All Rho, Rae, & Cdc42 40 investigators, therefore, have had to rely on techniques such as microinjection or permeabilization to achieve adequate cellular uptake of C3.